Thyroid disorders, hyperprolactinemia and systemic lupus erythematosus activity

Aim: The aim of this study was to determine the relationship between thyroid disorders and prolactin in patients with and without lupus activity. Patients & methods: Women with systemic lupus erythematosus (SLE) were evaluated for lupus activity. Serum tri-iodothyronine (T3), serum thyroxine (T4) and thyroid-stimulating hormone (TSH), anti-thyroid peroxidase (anti-TPO) anti-thyroglobulin (anti-TG) and prolactin were measured. Results: 50 women with SLE with lupus activity and 50 women with SLE without activity with mean age of 34.5 ± 14.8 years and mean disease duration of 15.0 ± 2.8 years. Patients with disease activity, subclinical hypothyroidism, anti-TG and anti-TPO were more prevalent and had higher prolactin levels compared with those without disease activity. There was no difference in prolactin levels according to the presence of hypothyroidism, and antithyroid antibody positivity did not differ in patients with and without hyperprolactinemia. Conclusion: There was no relationship between thyroid ...