[Efficacies of ¹³¹I-chTNT plus radiofrequency ablation for the treatment of advanced hepatocellular carcinoma].

Objective To evaluate the efficacies of radiofrequency ablation (RFA) plus iodine (131I) tumor necrosis therapy monoclonal antibody (131I-chTNT) for advanced stage hepatocellular carcinoma. Methods The clinical data of 38 hepatocellular carcinoma patients confirmed clinically or pathologically were retrospectively analyzed.They were divided into 2 groups (RFA group, n=22; combination group, n=16) according to the treatment mode.The median follow-up period was 31 (8-49) months.Survival was estimated with the Kaplan-Meier method and the survival curve compared by log-rank test. Results Thirteen cases in RFA group and 7 cases in combination group died of tumor progression or complications of liver cirrhosis.The median survival time in combination group was significantly than RFA group (43 vs 37 months) (P=0.039). The overall survival rates at 1, 2 and 3 years (100%, 87.5%, 75% respectively) were higher than those in RFA group (81.8%, 58.2%, 51.7% respectively). Conclusion For hepatocellular carcinoma with a special site and a diameter ≥5 cm, RFA plus 131I-chTNT treatment can prolong progression-free survival time.And its short-term curative effect is better than that of RFA therapy.And the long-term outcomes may be further explored by a large-sample, multi-center and randomized trial. Key words: Liver neoplasms; Ablation techniques; Treatment outcome; Radiology, interventional