DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns

DNA–polymer conjugates are attractive materials that combine the programmability of nucleic acid assembly with polymer functionality. Now, through a DNA cube template, monodisperse polymer particles have been imprinted with several DNA strands in pre-designed orientations — each independently set and addressable. The resulting hybrid particles can further assemble into well-defined, non-centrosymmetric structures.