RESERPINE SUBSTANTIALLY LOWERS BLOOD PRESSURE IN PATIENTS WITH REFRACTORY HYPERTENSION, A PHENOTYPE OF ANTIHYPERTENSIVE TREATMENT FAILURE

Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office BP [AOBP] ≥ 130/80 mmHg & 24-hr ambulatory BP [ABP] ≥ 125/75 mmHg on ≥5 antihypertensive medications, including chlorthalidone & a mineralocorticoid receptor