Analysis of the Serum Calcium, Phosphorus and Intact Parathyroid Hormone of Diabtic Nephropgthy and Non-diabtic Nephropgthy Patients with Maintenance Hemodialysis

Objective: To compare the differences of serum calcium, phosphorus, intact parathyroid hormone(iPTH) levels and their changes in the hemodialysis course between diabtic nephropgthy and non-diabtic nephropgthy patients with maintenance hemodialysis, the correlation between serum levels of calcium(Ca), phosphorus(P), intact parathyroid hormone(iPTH) in both groups of patients were analyzed. Methods: A total of 148 patients with maintenance hemodialysis were surveyed in this study. Patients were divided into diabetic nephropathy(DN, n=58) and non- diabetic nephropathy group(non-DN, n=90). Clinical data were compared between the groups, correlations were analyzed between Ca, P, HbA1c and iPTH levels. Results: Serum iPTH and phosphorus were significantly lower in DN group than in non-DN group(P0.05). There was no significant difference of calcium between the DN and the non-DN patients. A negative correlation beteen iPTH and Ca(r=-0.320, P=0.036) and a positive correlation between iPTH and P(r=0.426, P =0.005) were found in the non-DN group. No significant correlation between iPTH, Ca and P was observed in the DN group. A negative correlation between Serum iPTH and HbA1c(r=-0.732, P=0.007) was showed in the DN group. Conclusion: Serum iPTH level and phosphorus were lower in diabtic nephropgthy haemodialysis patients than in non-diabtic nephropgthy patients, which indicate that high serum concentration of glucose suppresses iPTH secretion.