Lack of Association between ARMS2 Polymorphism and Age- Related Macular Degeneration among Jordanians

Multiple genetic factors have recently been characterized as risk factors for age-related macular degeneration (AMD). ARMS2 gene polymorphism, rs10490924, was associated with AMD. This case-control analyzed the role of ARMS2 gene among Jordanians with AMD. Forty two AMD patients and 84 controls were recruited and genotyped for rs10490924 of ARMS2 gene. Genotypic distribution of the ARMS2 polymorphism was not different among AMD patients compared to controls (p=0.20). Allelic distribution was also insignificant among AMD patients (allele frequency 0.33) compared to control (allele frequency 0.23). This study was the first that screen AMD ARMS2 gene polymorphism among Jordanians. Further studies with larger sample size and different set of patients might be needed to confirm our conclusion.