365: Gestational weight gain: What is optimal to improve perinatal outcome?

OUTCOME? YVONNE CHENG, JUDITH CHUNG, INGRID KURBSCH-BLOCK, MARIBETH INTURRISI, SHERRI SHAFER, AARON B CAUGHEY, University of California, San Francisco, San Francisco, California OBJECTIVE: To examine the association between gestational weight gain and perinatal outcome in women with gestational diabetes mellitus (GDM). STUDY DESIGN: This is a retrospective cohort study of women with non-anomalous singletons diagnosed with GDM who were enrolled in the California between 2001 and 2004. Gestational weight gain, calculated from prepregnancy weight and weight at last prenatal visit were subgrouped into 0, 1-14, 15-35, and 35lbs. Perinatal outcomes were using chi-squire test and potential confounders were controlled for using multivariable regression analysis with 15-35lb weight gain as the reference group. RESULTS: Of the 31,699 women with GDM, 4.5% had weight loss, 21.8% gained 1-14lbs, 57.4% gained 15-35lbs, and 16.3% gained 35lbs during pregnancy. Gestational weight loss is associated with lower odds of LGA, cesarean, and neonatal NICU admission but higher odds of SGA while women with weight gain 35lbs have higher odds of LGA, preterm delivery and cesarean delivery but not SGA (see Table).