Efficacy of Continuous Intravenous Infusion of Somatostatin Combined with Omeprazole in Treatmeat for Acute Nonvariceal Upper Gastrointestinal Heavy Bleeding

2013 
Objective To observe the efficacy of continuous intravenous infusion of somatostatin combined with omeprazole in the treatmeat for acute nonvariceal upper gastrointestinal heavy bleeding.Methods 60 patients with acute nonvariceal upper gastrointestinal heavy bleeding were randomized divided into treatment group(n=30) and control group(n=30).Patients in treatment group received somatostatin 750ug i.v.and then continuous intravenous pump at a rate of 250 ug/h and then were given intravenous omeprazole 40mg first,then continuous intravenous pump at arate of 8mg/h.Patients in control group were given intravenous omeprazole 40 mg first,and then continuous intravenous pump at arate of 8mg/h.Results The effective rate of hemostasis in treatment group was 88.6%,much higher than that in control group(68.7%,P0.01).Conclusion Continuous intravenous infusion of somatostatin combined with omeprazole is more effective than intravenous infusion of omeprazole in controlling acute nonvariceal upper gastrointestinal heavy bleeding.
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