The effects of nonionic contrast media on renal function of elderly patients undergoing elective coronary angiography

Objective To investigate the effects of nonionic contrast media on renal function of elderly patients undergoing elective coronary angiography.Methods Forty-one elderly patients who were going to have coronary angiography and PCI were selected.All the patients were administered with ultravist(370).Cr,BUN,urine protein(PRO),urine β_2-microglobulin(β_2MG),urine micro-albumin(UMALB),Ucr,Ccr,free water clearance(CH_2O) were measured before angiography and on the second and fifth days after angiography.Results On the second day after angiography,Cr,BUN,urine micro-albumin(UMALB) were elevated and Ucr,Ccr decreased compared with those before angiography(P0.05).On the fifth day,they all returned to the pre-angiography level(P0.05).On the second day after angiography,CH_2O was elevated compared with that before angiography(P0.05).It did not return to the normal level on the fifth day(P0.05).Eight cases developed more than 25% decrease in Ccr within 48 hours after contrast administration.They were diagnosed as contrast medium-associated nephropathy(CAN).Conclusion In elderly patients undergoing coronary angiography,nonionic contrast media may cause adverse effects on renal function.However,most indexes may return to pre-angiography level on the fifth day after angiography.