Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

AbstractContext: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) – a source of oxidative stress – and CML.Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied.Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men.Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.Conclusion: Accumulation of CML may be an adverse health consequence of SDB