Abrupt Disruption of Nicotine Addiction and Apathy after a Strategic Acute Brain Ichemia (P05.123)

OBJECTIVE: To analyze shared mechanism of nicotine addiction and apathy by clinical assessment, magnetic resonance imaging (MRI) and Difussion Tensor Imaging(DTI). BACKGROUND: Cigarette addiction is related to the reward pathway that includes the tegmental area connected by the medial forebrain bundle (MFB) to the hypotalamus, accumbens nucleus (NAcc) and the fronto orbital cortex (FO). Apathy is related to the damage of the cingulated gyrus and disruption of networks connecting frontal structures with caudate nucleus, pallidum and thalamus. DESIGN/METHODS: RMI 1,5 tesla MRI and DTI, neuropsychiatric and cognitive assessment. RESULTS: A 62 year old patient with a history of active smoker (30 pack/year), Fagerstrom Nicotine Dependence Scale: 6 developed sudden onset of apathy (Starkstein Apathy Scale:38) with spontaneous cessation of cigarette smoking without withdrawal symptoms. Social withdraw and indifference was reported by relatives. No significant depressive symptoms were detected. Social Perception measured by "Reading the Mind in the Eyes" Test was abnormal. MRI showed an acute right FO stroke (medial and lateral FO cortex, frontal pole and underneath white matter); DTI showed decreased fiber density of cingulated bundle, uncinate faciculus and medial forebrain bundle in the right. NAcc was preserved. Old ischemic strokes located in the left caudate head and pallidum were detected as well. CONCLUSIONS: Immediate smoke cessation without withdrawal symptoms was observed after a FO lesion with disruption of pathways related to reward. Apathy is unusual in a small frontoorbital lesion. The cingulum bundle was affected without any evidence of anterior cingulum injury, suggesting that some circuits from FO cortex that are passing trough were theoretically related to apathy development. Apathy and smoke cessation could have been related to a “functional” bilateral fronto-subcortical circuit damage due to the combination of old left pallidal and caudate stroke with a deaferentation of the right basal ganglia. Disclosure: Dr. Bagnati has received personal compensation for activities with Novartis, Servier, and AstraZeneca Pharmaceuticals. Dr. Fernandez Suarez has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Chrem Mendez has nothing to disclose. Dr. Calvar has nothing to disclose. Dr. Vetrice has nothing to disclose. Dr. Meli has nothing to disclose. Dr. Campos has nothing to disclose. Dr. Amengual has received research support from FLENI. Dr. Cohen has nothing to disclose. Dr. Russo has nothing to disclose. Dr. Allegri has nothing to disclose.