C-peptide and renal protection in diabetes

Researches in both human and animal studies show that C-peptide plays a role in renal protection.In type 1 diabetic patients with chronic renal failure,residual pancreatic activity,restored by kidney-pancreas transplantation resulted in enhanced kidney graft survival,improvement of hypertrophy and vascular function.C-peptide can reduce diabetes-induced glomerular hyperfiltration,urinary protein excretion and urinary sodium wasting,therefore,resulting in regression of fibrosis.C-peptide ameliorates diabetes-induced functional and structural renal changes in animal models as well as in patients with type 1 diabetes.Studies have shown that the effects of C-peptide on renal function might involve in constriction of afferent arterioles,Na~+,K~+-ATPasc,biochemical changes in cell,inflammatory pathways and metabolic regulation. Key words: C-peptide ; Diabetes mellitus ; Renal protection