Development of a Point-of-Care diagnostic smart sensing system to detect creatinine levels

In this work, a non-invasive Electrochemical Impedance Spectroscopy (EIS) Point-of-Care (PoC) diagnostic device to detect the creatinine concentration from the serum is presented. A Micro-Electro-Mechanical Systems (MEMS) sensor was used for measuring the electrochemical properties of Sample Under Test (SUT). The EIS technique was utilised along with the sensor to find out different creatinine concentrations in heat-inactivated serum samples. Creatinine specific Molecularly Imprinted Polymerization (MIP)-coated sensor was used to measure the levels of creatinine followed by the development of a LoRaWAN-based PoC diagnostic device. In the next step, the results obtained from the diagnostic device were cross-verified by using standard Creatinine Colorimetric Assay Kit. The results were found to be promising to further continue the research.