Obstructive sleep apnea and the risk of chronic kidney disease – glomerular filtration rate estimations based on serum cystatin C and creatinine concentrations

Rationale: Some studies have demonstrated an association between chronic kidney disease (CKD) and obstructive sleep apnea (OSA). It was suggested that glomerular filtration rate estimations (eGFR) based on serum creatinine may be influenced by muscle abnormalities observed in OSA patients. Aim: The aim of this study was to compare the prevalence of CKD in OSA pts using eGFR estimations based on both cystatin C and creatinine serum concentrations. Materials and methods: A cohort of 240 pts with newly diagnosed OSA was enrolled into the study. Results: 185 males (77%) and 55 females (23%) with mean age = 56.8 ±9.9 yrs, Apnea-Hypopnea Index (AHI) 38.7±21.7/hour, Epworth sleepiness scale (ESS) 11.2± 5.7 were examined for CKD. Results of eGFR in studied group are listed below. View this table: Table1 View this table: Table2 Weak correlations were observed between eGFR estimated using cystatin C and: proBNP (R -0.24, p=0.0061), total cholesterol (R =0.16, p=0.015) and ESS (R -0.16 p=0.015). Conclusion: We have found a signs of CKD in a significant number of studied OSA pts. eGFR based on cystatin C increased prevalence and severity of CKD in OSA pts. Additional eGFR masurements based on cystatin C should be considered in OSA pts.