P0121 : Angiotensin II inhibition to treat severe liver fibrosis: A double-blind randomized trial (ANRS HC19)

lactulose use (corollary for HE, OR 1.6, p = 0.05) and male gender (OR 1.6, p = 0.05) predicted readmission while high serum albumin was protective (OR 0.57, p = 0.004). Infection as the index admission reason, diabetes or WBC were not predictive. Using index hospitalization discharge values: The only predictors of 3-month readmissions on discharge were MELD (OR 1.1, p = 0.002) and SBP prophylaxis (OR 1.95, p = 0.05). Nosocomial infections, diabetes, infections on admission and other medications were not predictive. Conclusions: Readmissions occurred in 50% of hospitalized cirrhotics within 3 months of discharge, regardless of infections being the reason for the index admission, in this prospective multi-center study. Without intervention, these pateints likely be readmitted, most commonly for infections. Strategies to prevent readmissions are urgently needed, especially in higher MELD patients with HE and lower serum albumin who are on SBP prophylaxis.