The cryptic path from epitope to clot: a story of 2 domains?

Comment on de Laat et al, page [1540][1]; and Kuwana et al, page [1552][2] Our understanding of the pathogenesis of antiphospholipid syndrome is incomplete but in this issue, 2 papers, by Kuwana and colleagues and de Laat and colleagues, give significant new insights into the mechanisms underlying