Tu1236 Participation of the Bile Acid in Low-Dose Aspirin-Induced Small Intestinal Mucosal Injury

was impaired in the SERT KO rats at 120 hours as seen by a larger wound area (0.138 ± 0.053 vs 0.384 ± 0.086 mm2, P < 0.05). Higher 5-HT levels were found along the wound edge compared to normal mucosa (627 ± 228 vs 318 ± 143 nM, P < 0.0005). Conclusions: Decreased 5-HT uptake with increased extracellular 5-HT levels are associated with decreased mucosal growth and impaired wound healing. Focal damage to the mucosa results in elevated 5-HT along the wound edge. These results suggest an important role of 5-HT in regulating responses to damage and maintaining intestinal homeostasis. (Supported by the Division of Neonatology at Michigan State University and by an AAP Resident Research Grant to MP).