Satisfactory control of bowel urgency and global improvement in irritable bowel syndrome (IBS) with Lotronex® (Alosetron HCl) therapy

Purpose: Bowel urgency is one of the most bothersome symptoms for subjects with nonconstipated IBS, affecting subjects on over 70% of days. This study screened for subjects with bowel urgency and compared treatment with Lotronex to placebo. Furthermore, the impact on global improvement of IBS symptoms and the relationship between global improvement and satisfactory control of urgency was evaluated.