Analysis of rational clinical uses of traditional Chinese medicine injections and factors influencing adverse drug reactions

Objective:To rationalize the clinical use and safety are some of the key issues in the surveillance of traditional Chinese medicine injections(TCMIs).Method:In this 2011 study,240 medical records of patients who had been discharged following treatment with TCMIs between 1 and 12 month previously were randomly selected from hospital records.Consistency between clinical use and the description of TCMIs was evaluated.Research on drug use and adverse drug reactions / events using logistic regression analysis was carried out.Result:There was poor consistency between clinical use and best practice advised in manuals on TCMIs.Over-dosage and overly concentrated administration of TCMIs occurred,with the outcome of modifying properties of the blood.Logistic regression analysis showed that,drug concentration was a valid predictor for both adverse drug reactions / events and benefits associated with TCMIs.Conclusion: Surveillance of rational clinical use and safety of TCMIs finds that clinical use should be consistent with technical drug manual specifications,and drug use should draw on multi-layered logistic regression analysis research to help avoid adverse drug reactions / events.