Influence of Premedication with Lorazepam on Plasma Cortisol and Blood Sugar

An attempt was made to quantify sedation with lorazepam in terms of changes in plasma Cortisol and blood sugar and to compare the results with clinical observation. The results indicate that lorazepam caused satisfactory preoperative sedation when compared with the findings in the patients given placebo. In conformity with its adequate sedative effect, lorazepam caused decrease in both the plasma Cortisol and blood sugar in the samples obtained in the anaesthetic room.