Information feedback of 18F-FDG PET/CT computer imaging combined with tumor markers on recurrence and metastasis of non-small cell lung cancer

Abstract To investigate the diagnostic value or information feedback of tumor markers combined with 18 F-FDG PET/CT computer imaging on recurrence and metastasis of non-small cell lung cancer (NSCLC). Methods From January 2013 to December 2017, 95 NSCLC patients undergoing systemic 18 F-FDG PET/CT computer imaging examination at the PET/CT computer imaging center of Mudanjiang Medical University had been enrolled. Typically, the interval between the completion of treatment and PET/CT computer imaging examination should be at least three months. Besides, all patients had undergone serum CEA monitoring before and after 18 F-FDG PET/CT computer imaging, and 70 of them had received CYFRA21-1 test at the same time. Tumor markers were examined with PET/CT at intervals of less than one week, and all the feedback results were compared with clinical follow-up results or final pathology. Additionally, all the enrolled patients were followed up for 6–12 months. Results The sensitivity, accuracy, specificity, positive predictive value and negative predictive value of 18 F-FDGPET/CT information feedback in evaluating recurrence or metastasis after NSCLC treatment were superior to those of common tumor markers, and the differences were statistically significant (P  18 F-FDG PET/CT computer imaging combined with tumor marker examination for the recurrence and/or metastasis after NSCLC treatment were remarkably higher than those of either individual examination, and the accuracy difference of information feedback had significant statistical significance (P  18 F-FDG PET/CT imaging, and the correlation coefficient was r = 0.63. Moreover, serum CEA was grouped at different levels, and the positive rate and accuracy of 18 F-FDG PET/CT computer imaging diagnosis were increased with the increase in CEA level. 8 patients had received 18 F-FDG PET/CT dual-phase examination, among them, 4 were diagnosed with recurrence or metastasis after MSCLC treatment, and all of them had been detected.