Performance of Medtronic Hybrid Closed-Loop Iterations: Results from a Randomized Trial in Adolescents with Type 1 Diabetes

Abstract This study investigates the performance of an iteration of the Medtronic hybrid closed-loop (HCL) algorithm, which utilizes sensor glucose values non-adjunctively for bolus advice, recognizes sustained hyperglycemia, suggests insulin bolus correction, and includes more accommodative SmartGuard™ automode parameters that aim to improve function and usability. Adolescents aged 13–17 years with type 1 diabetes >1 year, glycated hemoglobin (HbA1c) 7.0%–10%, currently using Continuous Subcutaneous Insulin Infusion were randomized to the control Medtronic standard HCL algorithm or to the intervention Medtronic HCL with enhancements. Participants attended a 7-day and 7-night nonstructured camp setting. Twelve participants (mean age 15 years, seven males, five females, mean HbA1c 8.55%) completed the study. For the control group, time in target glucose sensor range (3.9–10 mmol/L) was 63.68% ± 10.74% at baseline and changed to 75.85% ± 8.49% during the study (relative Δ19%). Time spent in <2.8 mmol/L was ...