Clinicopathological differences between hepatitis B viral genotype B and C-related resectable hepatocellular carciaom

Objective To investigate whether HBV genotypes B and C influence the clinicopath-ological features of patients with resectable HCC.Methods Stored serung samples from 58 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method.Results Of the 193 patients undergoing resection of HCC,18(31%)and 40(69%)were infeeted with geno-types B and C,respectively.Compared with genotype C patients,genotype B patients were less likely to be associated with liver cirrhosis(33% vs 70%,P=0.01).Pathologically,genotype B patient showed a higher rate of mutiple tumor(28%vs 7.5%,P=0.04)and more vascular invasion(33% vs 10%,P=0.03)than genotype C patients.Conclusion Genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of multiple tumour as well as more vascular invision than genotype Crelated HCC.These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection. Key words: Carcinoma hepatocellular; Genotype; Hepatitis B virus; Surgical resection