A dietary trial with a short-term low-sucrose diet in an Italian population: effects on colorectal mucosal proliferation.

Abstract Colorectal mucosal proliferation is supposed to predict colon cancer risk. We investigated whether a low‐sucrose diet might reduce colorectal mucosal proliferation in a group of patients at higher risk of colorectal cancer after at least two colon adenoma resections. In a pilot phase, 14 patients [12 men and 2 women, 60.3 + 5 (SD) yr] were instructed to adopt a low‐sucrose diet for one month. Colorectal biopsies were taken twice in the same patients, at the start and the end of the intervention period, and mucosal proliferation was measured by [3H]thymidine uptake in vitro and autoradiography. Although compliance of study participants to dietary modification was high, only a few agreed to two consecutive endoscopies; thus we carried out a randomized study, and 107 patients were assigned to a low‐sucrose diet (50 treated patients: 31 men and 19 women, 59.7 ± 7.5 yr) or instructed to continue their usual diet for one month (55 control patients: 32 men and 23 women, 59.6 ± 7.7 yr). At the end of thi...