PP14.2 – 2563: Early electrical brain activity in preterm neonates with very low birth weight with prolonged respiratory therapy without clinical and ultrasound features of acute brain damages

There is prevalence of neurodevelopmental impairment in children born extremely premature and in recent years it is observed and considers as a result of acute brains damage occurring during the first postnatal weeks. Development of methods that enable early identification of functional disorders and risk of acute brain injury in preterm infants is obvious necessary in NICU (neonatal intensive care unit). Aim To demonstrate the physiological features of brain activity in the early neonatal period in preterm infants receiving respiratory therapy (prolonger mechanical ventilation), with very low birth weights and gestational age up to 32 weeks, in acute neonatal period without clinical and brains images sings detecting by cranial ultrasound. Subjects: We studied 10 neurologically healthy preterm babies with prolonged mechanically ventilation, they gestation age was between 27–30 weeks (averages M=28.6±3.59 weeks), with averages weight birth (M) 1077±359 grams. Nobody obtained sedation therapy. Methods Scalp EEG was recorded with 8 electrodes on 3–5 days after birth, duration – 1 hour. Repeated cranial ultrasound investigations (cUS) were performed on days1, 3 and 7 and 4 weeks after birth. Results Structural brain changes has not been detected by cUS in all patients. Early EEG activity in all preterm patients consists of patterns discontinue: inter burst interval (IBI) and burst of electrical activity. Maximum duration of IBI was 8–25 sec, (M=15.8±10.45 sec), minimum duration – 4–12 sec (M=8, 2±6.28 s). Averages time of IBI in preterm infants with very low birth weight was 6–18.5 sec (M=11.4±8.97). Conclusion Study demonstrates that the electro-cortical background activity, in the early neonatal period in preterm infants with very low birth weight and receiving respiratory therapy (prolonger mechanical ventilation), without clinical and neuroimigine damage sings is presented by trace discontinue. The average durations of inter burst interval is 11.4±8.97 s.