Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the veterans affairs diabetes trial (VADT) cohort

Abstract Background To determine if serum pigment epithelium-derived factor (PEDF) levels predict cardiovascular events, renal dysfunction and mortality in the Veterans Affairs Diabetes Study (VADT). Methods PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urinary albumin creatinine ratio (ACR) ≥300 mg/g), or chronic kidney disease (CKD) stages 3 (eGFR Results In 743 participants, PEDF was measured at both time-points. PEDF increased over time from (mean ± SD) 10.5 ± 4.03 to 11.0 ± 4.86 ng/ml (paired t-test p = 0.0092). Lower eGFR (p  Conclusions Over 2-years, higher serum PEDF levels predicted advanced nephropathy in patients with type 2 diabetes.