Response to Comment on: Lin et al. (2010) Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59:2247-2252

The susceptibility and kinetics of diabetes induction following streptozotocin (STZ) administration is highly dependent on the specifics of the protocol (1). In our studies, we demonstrated that intraperitoneal administration of 40 mg/kg of STZ (Alexis Biochemicals, Farmingdale, NY) to male mice aged 6–10 weeks on 5 consecutive days induced autoimmune diabetes in wild-type (WT) C57BL/6 mice but not in congenic C3−/− …