Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease

Abstract Background and aim To explore associations between serum 25-hydroxyvitamin D 3 [25(OH)D] concentrations and liver histology in patients with non-alcoholic fatty liver disease (NAFLD). Methods and results We studied 60 consecutive patients with biopsy-proven NAFLD, and 60 healthy controls of comparable age, sex and body mass index (BMI). NAFLD patients had a marked decrease in winter serum 25(OH)D concentrations (51.0±22 vs. 74.5±15nmol/L, P P Conclusions Compared with controls, NAFLD patients have a marked decrease in serum 25(OH)D concentrations, which is closely associated with histopathological features of NAFLD. Further investigation into whether vitamin D 3 may play a role in the development and progression of NAFLD appears to be warranted.