Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance

Abstract Aims To assess circulating fetuin-B concentrations in subjects with different degrees of glucose tolerance and to analyze the association of fetuin-B concentrations with insulin resistance and the first phase of glucose-stimulated insulin secretion. Methods Plasma fetuin-B concentrations were analyzed in 149 subjects with normal glucose tolerance (NGT, n =54), impaired glucose regulation (preDM, n =42) and newly diagnosed type-2 diabetes mellitus (nT2DM, n =53). Intravenous glucose tolerance tests (IVGTTs) and biochemical parameters were also assessed in all participants. Results Plasma fetuin-B concentrations were significantly higher in nT2DM patients compared with NGT and preDM subjects (both P 1c , hsCRP, FINS and TG ( P P P Conclusion Patients with nT2DM have significantly higher concentrations of plasma fetuin-B compared with NGT subjects and plasma fetuin-B is strongly associated with glucose and lipid metabolism, chronic inflammation and first-phase glucose-stimulated insulin secretion and insulin resistance.