polymorphisms of the Tgfbrap1 gene in relation to blood pressure variability and plasma Tgf-β1

AbstractTGF-β receptor-associated protein 1 (TGFBRAP1), as a chaperone, binds Smad4 to participate in vascular development and remodeling which is closely related to the aetiology of essential hypertension (EH). Herein, the main aim of this study is to investigate the genetic susceptibility of TGFBRAP1 to hypertension. A case–control study comprising 2012 hypertension cases and 2210 controls was used to generate the hypothesis of the association of TGFBRAP1 gene with EH and another case–control study in a children population then proceeds to further replicate the association. Logistic regression model was used to adjust confounding factor for EH and general linear model (GLM) was applied to compare blood pressure levels and plasma TGF-β1 levels between genotypes in cases and controls. There was no statistical association with EH after the covariates were controlled for. However, quantitative trait analysis indicated that DBP had a linear decrease with the variations of rs2679860 (p = 0.005) after adjustme...