COMPARISON BETWEEN CARDIOVASCULAR TRIAL OUTCOMES AND TREATMENT EFFECTS USING CLINICAL ENDPOINT COMMITTEE ADJUDICATION VERSUS ROUTINE HEALTH DATA: A SYSTEMATIC REVIEW

We compared the incidence of cardiovascular (CV) events and estimated randomized treatment effects ascertained from routine health data (RHD) compared with traditional clinical endpoint committee (CEC) adjudication in CV randomized clinical trials (RCTs). We searched MEDLINE (1976 to July 2018) and