Recurrent transient increases in liver enzymes specifically after isoflurane anesthesia

: A 69 y-old female underwent orthopedic surgery 12 times in our hospital. A variety of agents were used for anesthesia. She developed episodes of transient increase in liver enzymes only after each of three isoflurane anesthesia (GOT : 311, 292, 328 IU.l-1, GPT: 341, 264, 274 IU.l-1). We suspected drug-induced liver dysfunction, but results of a lymphocyte stimulation test were negative. We conclude that her liver dysfunction was not severe enough to cause clinical symptoms. In such susceptible patients we should be careful of our choice of anesthetic drugs.