Methylnaltrexone reduces oral-cecal transit time in humans

using Wilcoxon's Signed Rank test. Results: The baseline serum leptin levels were 2.6 +/2.4 ng/mh Three days after leptin administration the serum levels wetz 2111.4 +A 555.1 ng/ml (P<0.C~1). No sigmficant difterences in gastric emptying could be observed. At baseline T1/2 was 98.9 +l559 rain and Tlag was 51.8 +/37 rain Three days after leptin administration T1/2 was 81.0 +/34.5 min and Tlag was 29.9 +/24.5 m m Pvalues were 031 and 0.11, respectively. Conclusions: Although there was a trend towards an accelerated gastric emptying, administration of 80 nag PEG-OB does trot significantly aifect the gastric emptying rate of a solid meal. *Hukshom et al. 2000 J Clin Endocrinol Metab 85:4003-4009.