IDDF2019-ABS-0271 Liver stiffness measurement in non-alcoholic fatty liver disease: two is better than one

Background Repeating liver stiffness measurement (LSM) was recently reported to improve diagnostic accuracy in patients with non-alcoholic fatty liver disease (NAFLD). However, there are to date no other studies confirming this finding. Aim To evaluate the accuracy of repeating LSM for the diagnosis of NAFLD with high liver stiffness measurement. Methods Adult NAFLD patients who had two FibroScan within 6 months prior to liver biopsy in a university hospital were included. F3-F4 fibrosis was excluded using LSM cut-off of 7.9kPa. Results A total of 140 patients were recruited. 85% (119/140) patients had high LSM (≥7.9kPa) on baseline scan. Among them, 27% (32/119) had low LSM ( Conclusions False positive diagnosis of advanced fibrosis in NAFLD patients can be reduced and unnecessary liver biopsy can potentially be avoided by repeat LSM.