Does progesterone supplementation improve pregnancy rates in clomiphene citrate and intrauterine insemination treatment cycles

AbstractAim: To investigate the effect of empiric use of luteal phase progesterone supplementation to improve endometrial receptivity in women undergoing treatment with clomiphene citrate in combination with intrauterine insemination (CC-IUI).Design: Retrospective cohort analysis.Setting: University fertility center.Patients: 426 CC-IUI cycles from 292 patients with unexplained infertility.Interventions: Patients were treated with micronized intravaginal progesterone 100 mg twice daily beginning approximately three days after CC-IUI.Main outcome measure(s): Clinical pregnancy per initiated cycle as defined by presence of fetal heart rate on ultrasound.Results: Clinical pregnancy rate was higher in patients receiving luteal phase support compared to patients not receiving luteal phase support (odds ratio: 2.04; 95% confidence interval: 1.01–4.14) after adjusting for all factors in the analysis using a multivariate logistic regression model. Age at the start of the cycle, BMI and CC dose were not shown to h...