Serum Biomarkers As a Diagnostic Aid in Acute Appendicitis

Background: Acute appendicitis is one of the most common acute intra-abdominal infections seen in surgical departments, which can be treated easily if an accurate diagnosis is made on time. Otherwise, delay in diagnosis and treatment can lead to perforation of the appendix d 6 patients had a normal CRP level. Thus, TLC had a sensitivity, speci?city &positive predictive value of 87.23%, 44.44% and 89.13% respectively. CRP had a sensitivity, speci?city & positive predictive value of 93.61%, 77.77% and 95.65% respectively. Percentage of neutrophil count had a sensitivity, speci?city & positive predictive value of 92.55%, 38.88%, 88.77% respectively. When used in combination, there was a marked improvement in the sensitivity, speci?city and the positive predictive value to98.76%, 86.66% and 97.56% respectively. Conclusion: The in?ammatory markers, i.e., TLC, CRP and neutrophil count can be helpful in the diagnosis when measured together as this increases their sensitivity, speci?city & positive predictive value significantly.