Increased dietary zinc and vitamin B-2 is associated with increased alanine aminotransferase in Taiwanese adolescents.

Objective: Alanine aminotransferase (ALT) is generally used for evaluating liver function, and its concentrations are closely associated with sex and nutritional status. This study investigates the relationships between dietary components and serum ALT activity in Taiwanese adolescents. Methods: Data were collected from 1941 adolescents aged 13-18 years who participated in the fourth National Nutrition and Health Survey in Taiwan (2010-2011, adolescents). Results: The mean age was 15.3±0.1 y (15.3±0.1 y for boys and 15.2±0.1 y for girls). Mean serum ALT was 14.8±13.3 U/L (17.7±16.3 U/L for boys and 12.1±8.7 U/L for girls; p＜0.001). Multivariate analysis revealed that, among girls, a single-unit increase in dietary zinc was associated with 1.123- and 1.108-fold increases in risk for increased serum ALT tertile 2 (T2) and T3, respectively, compared with T1; and a single-unit increase in vitamin B_2 intake increased risk by 1.708- and 1.540-fold, respectively. Further analysis revealed that the risk increase for boys and girls who consumed the highest amounts of dietary zinc and vitamin B_2 (T3) was 1.970-and 2.618-fold, respectively; they were also more likely to have higher serum ALT (＞11 U/L for boys and ＞9 U/L for girls) than those of the reference (presented as zinc T1 and vitamin B1 T1). Conclusions: Increased dietary zinc and vitamin B_2 intake is associated with higher serum ALT in adolescents.