The association between neuromuscular blockade use during target temperature management and neurological outcomes

Abstract Background To date, no study has comprehensively analyzed the association between neuromuscular blockade (NMB) during target temperature management (TTM) and the neurological outcomes after out-of-hospital cardiac arrest (OHCA) using a multicenter dataset. We aimed to examine the association between NMB during TTM after cardiac arrest and neurological outcomes after OHCA. Methods This study was a secondary analysis of the Japanese Population-based Utstein-style study with defibrillation and basic/advanced Life Support Education and implementation-Hypothermia (J-PULSE-HYPO) study registry. The exposure of the current study was the use of NMB during TTM. The primary outcome was favorable neurological outcome, i.e., a cerebral performance category of 1–2, at hospital discharge. Results Of the 452 patients with OHCA enrolled in the J-PULSE-HYPO study, 431 were analyzed. NMB was used in 353 patients (81.9%). Multivariable logistic regression analysis revealed that NMB use was not independently associated with favorable outcomes [odds ratio (OR), 0.96; 95% confidence interval (CI), 0.42–2.18; p = .918)] or survival at discharge (OR, 0.83; 95% CI, 0.31–2.02; p = .688). After adjusting the covariates, the predicted probabilities did not reveal significant differences between NMB use and non-NMB use in the respective mean (95% CI) values for favorable neurological outcomes [53.6 (50.2–57.0) % vs. 58.0 (50.4–65.6) %, p = .304], and survival rates [77.1 (74.7–79.5) % vs. 75.8 (70.5–81.0) %, p = .647]. Conclusions The NMB use during TTM was not associated with favorable neurological outcomes and survival rate in patients with OHCA.