Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Kate M. Herum,Andreas Romaine,Ariel Wang,Arne Olav Melleby,Mari E. Strand,Julian Pacheco,Bjørn Braathen,Pontus Dunér,Theis Tønnessen,Ida G. Lunde,Ivar Sjaastad,Cord Brakebusch,Andrew D. McCulloch,Maria F. Gomez,Cathrine R. Carlson,Geir Christensen

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

2020

Kate M. Herum
Andreas Romaine
Ariel Wang
Arne Olav Melleby
Mari E. Strand
Julian Pacheco
Bjørn Braathen
Pontus Dunér
Theis Tønnessen
Ida G. Lunde
Ivar Sjaastad
Cord Brakebusch
Andrew D. McCulloch
Maria F. Gomez
Cathrine R. Carlson
Geir Christensen

Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated...

Keywords:

Internal medicine
Thrombin
Cardiology
Osteopontin
Medicine
Diabetes mellitus
Myofibroblast
Pressure overload
Syndecan 1
Cardiac fibrosis
Extracellular matrix

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