Effect of maximum body weight on early-phase insulin secretion of type 2 diabetes mellitus

Objective To analyze the effect of maximum body weight on early-phase insulin secretion of type 2 diabetes mellitus (T2DM). Methods A total of 651 patients with T2DM in Zhengzhou People’s Hospital from January 2016 to January 2017 were collected to record their disease history and measure the biochemical indicators. And the effects of maximum body weight on early-phase insulin secretion were measured. Results The course of disease (r=-0.167, P=0.003), the time from losing heaviest body weight to now (r=-0.145, P=0.013), HbA1c (r=-0.232, P=0.000) and fasting blood-glucose (r=-0.306, P=0.000) were negatively correlated with the early-phase insulin secretion, and body mass index (BMI) (r=0.182, P=0.001), max BMI(r=0.196, P=0.000) and LDL-C(r=0.191, P=0.025) were positively correlated with the early phase insulin secretion. Multiple linear regression analysis showed that the max BMI(t=2.759, P=0.007) was an independent correlation factor of insulin secretion in the early phase. Conclusions The max BMI continuously affects the early-phase insulin secretion of T2DM. Key words: Diabetes mellitus; Maximum body mass index; Early-phase insulin secretion