TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

// Bang-Dang Chen 1, 2, * , Xiao-Cui Chen 1, 2, * , Shuo Pan 3, * , Yi-Ning Yang 1, 2 , Chun-Hui He 2 , Fen Liu 1, 2 , Xiang Ma 1, 2 , Min-Tao Gai 1, 2 , Yi-Tong Ma 1, 2 1 Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 2 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 3 First Department of Cardiology, People’s Hospital of Shaanxi Province, Xi’an, China * These authors contributed equally to this work Correspondence to: Yi-Tong Ma, email: myt-xj@163.com Keywords: hyperuricemia, HNF4G, single nucleotide polymorphism, genetic, case-control association study Received: January 23, 2017      Accepted: February 20, 2017      Published: March 02, 2017 ABSTRACT The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma ( HNF4G ) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Data were analyzed for two separate groups: men and women. For rs2941484, the genotype distribution frequency in hyperuricemic subjects and was significantly different from that in normouricemic controls in men ( P = 0.038). Meanwhile, in recessive model of rs2941484, the distribution frequency of TT genotype and CC+CT genotypes also differed significantly between the hyperuricemia men and normouricemic men ( P = 0.011). For the other 3 SNPs in both men and women, there was no difference in the genotype and allele and distribution frequency between the hyperuricemia patients and normouricemic controls. In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001). Therefore, TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men.