Curative Effect of Ginkgo Biloba Tablets Combined with Sotalol in the Treatment of Arrhythmia and the Influence on Cardiac Function, Ventricular Muscle Stability and Blood CRP, VIP and Ang II levels

Objective To explore the curative effect of Ginkgo biloba tablets combined with sotalol in the treatment of arrhythmia and the influence on cardiac function, ventricular muscle stability, blood C reactive protein (CRP), vasoactive intestinal peptide (VIP) and angiotensin Ⅱ (Ang Ⅱ) levels. Methods One hundred and twenty four patients with arrhythmia treated in our hospital were selected as subjects, and they were divided into the combined group and the control group with 62 cases in each group by the random number table method.The control group were treated with sotalol alone, while the combined group were treated with Ginkgo biloba tablets combined with sotalol.Changes in cardiac function [left ventricular ejection fraction(LVEF), stroke volume (SV)], ventricular muscle stability [T peak end interval (Tpe), corrected QT dispersion (QTcd)], inflammatory factors [CRP, monocyte chemoattractant protein -1 (MCP-1)], nerve messenger molecules [VIP, nitric oxide (NO)] and hypertension markers [Ang Ⅱ, aldosterone (ALD)] before the treatment and after 1 month of treatment were compared between the two groups.The therapeutic effects in two groups after 1 month of treatment and the incidence of adverse drug reactions within 1 month were analyzed. Results After 1 month of treatment, the LVEF, SV, VIP and NO level in the two groups were significantly increased, showing the combined group>the control group (all P 0.05). Conclusion Ginkgo biloba tablets combined with sotalol can obviously improve the cardiac function and ventricular muscle stability in patients with arrhythmia, and the treatment also can effectively improve the plasma levels of CRP, VIP and Ang Ⅱ. Key words: Ginkgo biloba tablets; Sotalol; Arrhythmia; Cardiac function; Ventricular muscle stability