ПЕРСОНАЛИЗИРОВАННЫЙ ПОДХОД К ЛЕЧЕБНО-РЕАБИЛИТАЦИОННЫМ МЕРОПРИЯТИЯМ У ПАЦИЕНТОВ С СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ (НА МОДЕЛИ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ И ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ)

Aim. To evaluate the experience of the usage of Pantogam active (PIQ-PHARMA LLC,Russia) under the concept of personalized approach to correction of cognitive and emotional (anxiety and depression) disorders in arterial hypertension (AH) and chronic heart failure (CHF). Material and methods. The analysis has been done, of three recent trials came out with the results showing efficacy of D-,L-Hopanthenic/rac-Hopanthenic acid (Pantogam active compound for non-cardiac pathology (AH and CHF). The endpoints of efficacy control were the grade of cognition reduction, emotional correction (anxiety and depression), life quality improvement. Also, the influence of the drug was evaluated, on the parameters of cardiovascular system. Results. In the 3 studies, totally 232 patients participated, with cardiovascular diseases (CVD), of those 147 were controls. Duration of Pantogam active intake lasted for 4 to 12 weeks. Responders by the parameter of cognitive function were 78-100%, for emotional disorders — to 88%, for life quality improvement — 86%. Tolerance of the therapy was evaluated as good, and minimal side effects were reduced within the first week of treatment. Conclusion. Application of Pantogam active for complex treatment of AH and CHF patients leads to correction of comorbid cognitive and emotional disorders, with the absence of tolerance, hyperstimulation and withdrawal syndrome, improves life quality, contributes to therapy effectiveness of main CVD and improvement of cardiovascular parameters (blood pressure, heart rate variability, exercise tolerance).