Comment: Tau vs 14-3-3 protein—Adjuncts for the diagnosis of CJD

Creutzfeldt-Jakob disease (CJD) has an annual incidence of 1 per million persons. With ∼300 US cases per year, and over 15,000 neurologists, we see a patient with CJD, by chance, once in 50 years of clinical practice. How does the accuracy of CSF tau vs 14–3-3 protein affect clinical diagnosis? There are 2 critical reasons to diagnose CJD accurately: first, to assure adequate precautions …