Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension
2013
Background/Aim. Identification of patients with arterial hypertension and a
possible onset of heart failure by determining the concentration of
N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely
intensification of treatment and allows clinicians to prescribe and implement
optimal and appropriate care. The aim of this study was to evaluate NT-proBNP
in patients with longstanding hypertension and in patients with signs of
hypertensive cardiomyopathy. Methods. The study involved 3 groups, with 50
subjects each: “healthy” persons (control group), patients with hypertension
and normal left ventricular systolic function (group 1) and patients with
longstanding hypertension and signs of hypertensive cardiomyopathy with
impaired left ventricular systolic function (group 2). We measured levels of
NT-proBNP, Creactive protein and creatinine according to the manufacturer’s
instructions. All the patients were clinically examined including physical
examination of the heart with blood pressure, pulse rate, electrocardiogram
(ECG) and echocardiogram. Results. Our results showed that the determined
parameters generally differed significantly (Student’s t-test) among the
groups. The mean (± SD) values of NT-proBNP in the control group, group 1 and
group 2 were: 2.794 (± 1.515) pmol/L, 9.575 (± 5.449) pmol/L and 204.60
(84,93) pmol/L, respectively. NTproBNP correlated significantly with the
determined parameters both in the group 1 and the group 2. In the group 1,
the highest correlation was obtained with Creactive protein (r = 0.8424). In
the group 2, the highest correlation was obtained with ejection fraction (r =
- 0.9111). NT-proBNP showed progressive increase in proportion to the New
York Heart Association (NYHA) classification. The patients in thegroup 2 who
belonged to the II and III NYHA class had significantly higher levels of
NTproBNP than those in the NYHA class I (ANOVA test, p = 0.001). Conclusion.
The obtained results suggest that NTproBNP is a useful biomarker in the
treatment of patients with longstanding hypertension who are at risk for
heart failure. [Projekat Ministarstva nauke Republike Srbije, br. 175036]
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