Evaluation of Antidiabetic activity of crude extracts of bark of Terminaliapaniculata Roth in Streptozotocin induced Diabetes in Wister Rats

The objective of the present study was to evaluate antidiabetic activity of petroleum ether (PETP) and ethanolic (EtTP) extracts of bark of Terminalia paniculata Roth (Family: Combretaceae) in normal and Streptozotocin induced diabetic rats. The extracts of Terminalia paniculata was investigated for antidiabetic activity in Streptozotocin induced diabetic rats by oral administration of extract 100 mg.kg body weight for single-dose one day and multiple-dose seven days. The effect was compared with oral dose of 0.5 mg.kg body weight Gilbenclamide. The determination of serum glucose level was estimated by the enzymatic glucose oxidase method. The results showed that Petroleum ether and Ethyl acetate extracts of bark of Terminalia paniculata significantly lowered the serum glucose levels. The efficacy of Petroleum ether extract was better than Ethyl acetate extract. Phytochemical study showed the presence of alkaloids, carbohydrate, flavanoids, phenolics, steroids and alkaloids. Therefore, this study shows that Terminalia paniculata has antidiabetic action and the extracts should be further be subjected to bioactivity graded drug discovery to isolate a lead compound responsible for this activity