Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen

Purpose Amikacin requires pharmacodynamic targets of peak serum concentration (C max) of 8–10 times the minimal inhibitory concentration, corresponding to a target C max of 60–80 mg/L for the less susceptible bacteria. Even with new dosing regimens of 25 mg/kg, 30 % of patients do not meet the pharmacodynamic target. We aimed to identify predictive factors for insufficient C max in a population of critically ill patients.