Abstract P126: Regulation of Short Chain Fatty Acid Receptors in the Kidney by microRNAs is Influenced by Hydrogen Sulfide Supplementation

Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined. Hydrogen sulfide (H2S) is an important gasotransmitter involved in multiple physiological processes and is known to alleviate adverse effects of hypertension such as reducing inflammation in the kidney. To determine the role of host microRNAs in regulating short chain fatty acid receptors in the kidney as well as the gut, C57BL/6J wild-type mice were treated with or without Ang-II (1000 ng/kg-1/min-1) and H2S donor GYY4137 (GYY) (133 μM/kg-1/d-1) for 4 weeks to assess whether GYY would normalize a...