Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients

Michael Schleibinger,Cathérine L. Steinbach,Christoph Töpper,Alexander Kratzer,Uwe Liebchen,Frieder Kees,Bernd Salzberger,Martin G. Kees

Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients

2015

Michael Schleibinger
Cathérine L. Steinbach
Christoph Töpper
Alexander Kratzer
Uwe Liebchen
Frieder Kees
Bernd Salzberger
Martin G. Kees

Aims The aim of the present study was to assess the pharmacokinetics of total and unbound ceftriaxone in intensive care unit (ICU) patients and its protein binding characteristics.

Keywords:

Anesthesia
Plasma protein binding
Pharmacodynamics
Cystatin C
Intensive care medicine
Pharmacokinetics
Intensive care unit
Medicine
Ceftriaxone
critical illness
Metabolic clearance rate
Dosing

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