Penetration of Ciprofloxacin into Human Peritoneal Tissue Following a Single Oral Dose of 750 Milligrams

SummaryThe penetration of ciprofloxacin into the peritoneal tissue was studied in 10 patients after a single oral dose of 750 mg given 5.6 hours (mean) before elective laparotomy. The mean tissue level was 0.29 μg/ml (range, 0.082 to 0.96 μg/ml) while the mean concomitant serum level was 1.3 μg/g (range, 0.52 to 2.57 μg/g). The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.